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Article

Differential role of the NLRP 3 inflammasome in infection and tumorigenesis

22 Jan 2019

Abstract excerpt

Dysregulated inflammation is one of the hallmarks of cancer initiation and progression. Emerging evidence indicates that inflammasomes play a central role in regulating immune cell functions in various infections and cancer. Inflammasomes are multimeric complexes consisting of nucleotide-binding oligomerization domain (NOD) -like receptors (NLRs). Among the NLRs, NOD1, NOD2 and NLRP3 respond to a variety of...

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PMID: 30666624
DOI: 10.1111/imm.13046

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