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The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery and drives alternative splicing

2021-12-09

Abstract excerpt

Aberrant RNA splicing contributes to the pathogenesis of many malignancies including Acute Myeloid Leukemia (AML). While mutation is the best described mechanism underpinning aberrant splicing, recent studies show that predictions based on mutations alone likely underestimate the extent of this dysregulation. Here, we show that elevation of the eukaryotic translation initiation factor eIF4E reprogrammes splicing o...

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Identifiers and source

Literature Corpus work
b3d994a2-badc-522b-a63a-a1f2ca1ce442
DOI
10.1101/2021.12.07.471666
Open publication

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The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery and drives alternative splicingDOI 10.1101/2021.12.07.471666
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