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Article

Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia.

Cancer research - 15 May 2024

Jin Peng, Wang Xiaoling, Jin Qiqi, Zhang Yi, Shen Jie, Jiang Ge, Zhu Hongming, Zhao Ming, Wang Dan, Li Zeyi, Zhou Yan, Li Wenzhu, Zhang Wei, Liu Yabin, Wang Siyang, Jin Wen, Cao Yuncan, Sheng Guangying, Dong Fangyi, Wu Shishuang, Li Xiaoyang, Jin Zhen, He Mengke, Liu Xiaxin, Chen Luonan, Zhang Yunxiang, Wang Kankan, Li Junmin

Abstract excerpt

Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies to improve AML patient outcomes. Herein, we retrospectively analyzed the multiomics data of more than 1,500 AML cases and found that patients with spliceosome mutations had a higher risk of developing refractory disease. RNA...

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Topics

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Share to Cell Line, Tumor
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Protein Biosynthesis

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Share to Splicing Factor U2AF

Source

Identifiers

PMID: 38417135
DOI: 10.1158/0008-5472.CAN-23-2543

Genes

U2AF1
EIF4A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia.PMID 38417135Read ↗

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