Article
RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2020
Anande Govardhan, Deshpande Nandan P, Mareschal Sylvain, Batcha Aarif M N, Hampton Henry R, Herold Tobias, Lehmann Soren, Wilkins Marc R, Wong Jason W H, Unnikrishnan Ashwin, Pimanda John E
Abstract excerpt
PURPOSE: RNA splicing is a fundamental biological process that generates protein diversity from a finite set of genes. Recurrent somatic mutations of splicing factor genes are common in some hematologic cancers but are relatively uncommon in acute myeloid leukemia (AML, < 20% of patients). We examined whether RNA splicing differences exist in AML, even in the absence of splicing factor mutations. EXPERIMENTAL...
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