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Article

RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies.

Journal of leukocyte biology - 1 Feb 2023

Li Zhenzhen, He Zhongzheng, Wang Jihan, Kong Guangyao

Abstract excerpt

RNA splicing, a crucial transesterification-based process by which noncoding regions are removed from premature RNA to create mature mRNA, regulates various cellular functions, such as proliferation, survival, and differentiation. Clinical and functional studies over the past 10 y have confirmed that mutations in RNA splicing factors are among the most recurrent genetic abnormalities in hematologic neoplasms,...

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PMID: 36822179
DOI: 10.1093/jleuko/qiac015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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