Article
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.
The EMBO journal - 3 Apr 2023
Ghram Mehdi, Morris Gavin, Culjkovic-Kraljacic Biljana, Mars Jean-Clement, Gendron Patrick, Skrabanek Lucy, Revuelta Maria Victoria, Cerchietti Leandro, Guzman Monica L, Borden Katherine L B
Abstract excerpt
Aberrant splicing is typically attributed to splice-factor (SF) mutation and contributes to malignancies including acute myeloid leukemia (AML). Here, we discovered a mutation-independent means to extensively reprogram alternative splicing (AS). We showed that the dysregulated expression of eukaryotic translation initiation factor eIF4E elevated selective splice-factor production, thereby impacting multiple...
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