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Article

RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML

2020-01-11

Abstract excerpt

RNA splicing is a fundamental biological process that generates protein diversity from a finite set of genes. Recurrent somatic mutations of splicing factor genes are relatively uncommon in Acute Myeloid Leukemia (AML, < 20%). We examined whether RNA splicing differences exist in AML even in the absence of splicing factor mutations. Analyzing RNA-seq data from two independent cohorts of AML patients, we identified...

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Literature Corpus work
aac3b2f1-d3d5-5a12-b7e5-18c4b5a95dbc
DOI
10.1101/2020.01.10.895714
Open publication

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RNA splicing alterations induce a cellular stress response associated with poor prognosis in AMLDOI 10.1101/2020.01.10.895714
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