Back to search

Article

Association between DNMT3A-driven clonal hematopoiesis, trained immunity and immune cell function in obesity

2026-08-23

Abstract excerpt

Trained immunity and clonal hematopoiesis are two newly identified immunological phenomena that contribute to the pathophysiology of atherosclerotic cardiovascular disease. These two phenomena share some convergent molecular mechanisms, such as IL-1β being a central regulator and involvement of epigenetic enzymes. Therefore, we hypothesize that presence of clonal hematopoiesis driver mutations (CHDMs) can predispo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b3d5d0e3-d68d-5b15-a28b-3f6a6c54a545
DOI
10.64898/2026.08.20.26360882
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Association between DNMT3A-driven clonal hematopoiesis, trained immunity and immune cell function in obesityDOI 10.64898/2026.08.20.26360882
The association between clonal hematopoiesis driver mutations, immune cell function and the vasculometabolic complications of obesitySemantic proximity
Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.Semantic proximity
Clonal hematopoiesis and autoimmunity.Semantic proximity
Clonal haematopoiesis and dysregulation of the immune system.Semantic proximity
Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitorsSemantic proximity
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitroSemantic proximity
The impact of obesity-induced inflammation on clonal hematopoiesisSemantic proximity
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.Semantic proximity
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice.Semantic proximity
C1q reprograms innate immune memory.Semantic proximity
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease developmentSemantic proximity
The causes and consequences of trained immunity in myeloid cellsSemantic proximity
Select a neighboring publication to make it the new centre.