Article
C1q reprograms innate immune memory.
Frontiers in immunology - 1 Jan 2025
Jonkman Inge, Jacobs Maaike M E, Negishi Yutaka, van Heck Julia I P, Matzaraki Vasiliki, Martens Joost H A, Baltissen Marijke, Vermeulen Michiel, Fayad Zahi A, Teunissen Abraham J P, Mulder Willem J M, Hilbrands Luuk B, Joosten Leo A B, Netea Mihai G, Mhlanga Musa M, Rother Nils, Duivenvoorden Raphaël
Abstract excerpt
Innate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli. In addition to its function in host defense, trained immunity contributes to diverse immune-mediated diseases. We discovered that complement component 1q (C1q) is an effective modulator...
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