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Article

Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.

Journal of the American Heart Association - 16 Jan 2024

Tercan Helin, Cossins Benjamin C, van Deuren Rosanne C, Rutten Joost H W, Joosten Leo A B, Netea Mihai G, Hoischen Alexander, Bekkering Siroon, Riksen Niels P

Abstract excerpt

BACKGROUND: Obesity is accompanied by dysregulated inflammation, which can contribute to vasculometabolic complications including metabolic syndrome and atherosclerosis. Recently, clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a risk factor for cardiovascular diseases. We aimed to determine how CHIP is related to immune cell function, systemic inflammation, and vasculometabolic...

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Identifiers

PMID: 38214284
DOI: 10.1161/JAHA.123.031665
PMCID: PMC10926828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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