Article

Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis

2026-07-06

Abstract excerpt

<h4>ABSTRACT</h4> Cryptococcus neoformans is the predominant causative agent of cryptococcal meningitis in immunocompromised individuals. Conversely in immunocompetent individuals, C. neoformans establishes a latent pulmonary infection characterized by a paucity of clinical symptoms. Using a mouse inhalation model of latent C. neoformans infection, we previously showed that CD4 T-cells are necessary for prevent...

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Literature Corpus work: b373cbeb-b85e-5c67-8dae-f8684ad73191
DOI: 10.64898/2026.07.02.736061

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