Article

Mechanism of innate immune reprogramming by a fungal meningitis pathogen

2021-09-02

Abstract excerpt

How deadly fungal pathogens overcome mammalian innate immunity is largely unknown. Cryptococcus neoformans , the most common cause of fungal meningitis, induces a pathogenic type 2 response characterized by pulmonary eosinophilia and alternatively activated macrophages. Using forward genetics, we identified a fungal secreted protein, Cpl1, necessary and sufficient to enhance alternative activation of primary macr...

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Literature Corpus work: 43c37d24-3a68-552e-8615-1a727adb3114
DOI: 10.1101/2021.09.02.458767

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