Article

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence within pulmonary fungal granulomas

2025-05-27

Abstract excerpt

Inhaled fungal pathogens often generate granuloma-contained latent infections that can reactivate to cause invasive disease. However, the mechanisms underlying the inability to generate sterilizing immunity against latent infection remains poorly understood. Here, we leveraged spatial transcriptomics and flow cytometry to characterize the immune dynamics and cellular architecture of cryptococcal granulomas. Using...

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Identifiers and source

Literature Corpus work: f18068c3-c6cb-55c6-aea9-68ad16172a79
DOI: 10.1101/2025.05.23.655817

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