Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic Potential

25 Aug 2021

Abstract excerpt

The ubiquitin-proteasome system (UPS) mediated protein degradation is crucial to maintain quantitive and functional homeostasis of diverse proteins. Balanced cellular protein homeostasis controlled by UPS is fundamental to normal neurological functions while impairment of UPS can also lead to some neurodevelopmental and neurodegenerative disorders. Functioning as the substrate recognition component of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34512273
DOI: 10.3389/fncel.2021.736008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic PotentialPMID 34512273Read ↗

FBXW7-Related Neurodevelopmental Disorder: Clinical Spectrum, Molecular Mechanisms, and Tumor Predisposition.Semantic proximity Read ↗

Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative DiseasesSemantic proximity Read ↗

Recent Insight on Regulations of FBXW7 and Its Role in ImmunotherapySemantic proximity Read ↗

Role of USP13 in physiology and diseasesSemantic proximity Read ↗

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read ↗

Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental DisordersSemantic proximity Read ↗

Emerging roles for E3 ubiquitin ligases in neural development and diseaseSemantic proximity Read ↗

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanismsSemantic proximity Read ↗

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.Semantic proximity Read ↗

The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond MovementSemantic proximity Read ↗

E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseasesSemantic proximity Read ↗

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.