Article
DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases
2023-09-12
Abstract excerpt
The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins. Ubiquitination can alter protein functions and/ or marks ubiquitinated proteins for proteasomal degradation but deubiquitinases (DUBs) can reverse protein ubiquitination. While the importance of DUBs as re...
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Identifiers and source
- Literature Corpus work
- f66aaa6e-ad3c-5eb0-9604-1af5b6bb9ff8
- DOI
- 10.20944/preprints202309.0749.v1