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HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

1 Apr 2020

Abstract excerpt

Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and apoptosis. To date, 28 HECT E3 ubiquitin ligases have been identified in humans, and recent studies have begun to reveal how these enzymes control various cellular...

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PMID: 32265230
DOI: 10.1242/jcs.228072

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