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Ubiquitin system mutations in neurological diseases.

Trends in biochemical sciences - 1 Oct 2024

Zenge Colin, Ordureau Alban

Abstract excerpt

Neuronal ubiquitin balance impacts the fate of countless cellular proteins, and its disruption is associated with various neurological disorders. The ubiquitin system is critical for proper neuronal cell state transitions and the clearance of misfolded or aggregated proteins that threaten cellular integrity. This article reviews the state of and recent advancements in our understanding of the disruptions to...

Topics

Humans
Ubiquitin
Animals
Nervous System Diseases
Mutation
Ubiquitin-Protein Ligases
Neurodegenerative Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38972780
DOI: 10.1016/j.tibs.2024.06.011
PMCID: PMC11455613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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