Article

Effect of Disease Causing Missense Mutations on Intrinsically Disordered Regions in Proteins

2021-04-27

Abstract excerpt

It is well known that disease-causing missense mutations (DCMMs) reduce the structural stability/integrity of the proteins with well-defined 3D structures thereby impacting their molecular functions. However, it is not known in what way DCMMs affect the intrinsically disordered proteins (IDPs) that do not adopt well defined stable 3D structures. In order to investigate how DCMMs may impact intrinsically disordered...

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Literature Corpus work: b36dbe23-82b8-5593-a38e-7e7035722793
DOI: 10.1101/2021.04.26.441554

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