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Article

The Contribution of Missense Mutations in Core and Rim Residues of Protein-Protein Interfaces to Human Disease.

Journal of molecular biology - 28 Aug 2015

David Alessia, Sternberg Michael J E

Abstract excerpt

Missense mutations at protein-protein interaction sites, called interfaces, are important contributors to human disease. Interfaces are non-uniform surface areas characterized by two main regions, "core" and "rim", which differ in terms of evolutionary conservation and physicochemical properties. Moreover, within interfaces, only a small subset of residues ("hot spots") is crucial for the binding free energy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26173036
DOI: 10.1016/j.jmb.2015.07.004
PMCID: PMC4548493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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