Article

Molecular dynamics simulations of intrinsically disordered protein regions enable biophysical interpretation of variant effect predictors

2025-05-12

Abstract excerpt

<h4>Summary</h4> Predictive models for missense variant pathogenicity offer little functional interpretation for intrinsically disordered regions, since they rely on conservation and coevolution across homologous sequences. To understand the extent to which biophysics modulates model performance compared to genomic conservation, we model biophysics of IDRs explicitly for improved interpretation of variant effects...

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Literature Corpus work: ccf3a632-97b1-51a2-9352-fd4bc5ac7721
DOI: 10.1101/2025.05.07.652723

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