Article
Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins.
Current opinion in structural biology - 1 Jun 2015
Kucukkal Tugba G, Petukh Marharyta, Li Lin, Alexov Emil
Abstract excerpt
This review emphasizes the effects of naturally occurring mutations on structural features and physico-chemical properties of proteins. The basic protein characteristics considered are stability, dynamics, and the binding of proteins and methods for assessing effects of mutations on these macromolecular characteristics are briefly outlined. It is emphasized that the above entities mostly reflect global...
Topics
- Animals
- Genetic Predisposition to Disease
- Humans
- Models, Molecular
- Mutation
- Polymorphism, Single Nucleotide
- Protein Binding
- Protein Conformation
- Protein Interaction Maps
- Protein Stability
- Proteins