Article

Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases

2019-01-28

Abstract excerpt

Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations—whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as effective biomarkers. It may be emphasized that the effect of a mutation depends on various factors, including the type of...

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Literature Corpus work: bf3bd0c5-8518-5f82-9a8b-7dcfc889b74f
DOI: 10.20944/preprints201812.0273.v3

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