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Predictive Model for Single-Site Mutations That Change Intrinsically Disordered Protein Binding Energetics.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Chandra Soumyanetra, Varadarajan Raghavan

Abstract excerpt

Intrinsically disordered proteins (IDPs) are characterized by structural mobility and lack of stable tertiary structure. These are important for IDP functions and interactions with other protein partners. IDP binding modes are distinctly divergent from globular protein-protein interactions. Comprehensive studies on effects of mutations in this structurally distinct protein class of IDPs are limited, impeding the...

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PMID: 41174305
DOI: 10.1007/978-1-0716-4828-5_3

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