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Computational Approaches for Investigating Disease-causing Mutations in Membrane Proteins: Database Development, Analysis and Prediction.

Current topics in medicinal chemistry - 1 Jan 2022

Kulandaisamy Arulsang, Ridha Fathima, Frishman Dmitrij, Gromiha M Michael

Abstract excerpt

Membrane proteins (MPs) play an essential role in a broad range of cellular functions, serving as transporters, enzymes, receptors, and communicators, and about ~60% of membrane proteins are primarily used as drug targets. These proteins adopt either α-helical or β-barrel structures in the lipid bilayer of a cell/organelle membrane. Mutations in membrane proteins alter their structure and function, and may lead...

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PMID: 35894475
DOI: 10.2174/1568026622666220726124705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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