Article
Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells.
RNA biology - 1 Jan 2018
Yi Caihong, Li Guiming, Ivanov Dmitri N, Wang Zhonghua, Velasco Mitzli X, Hernández Greco, Kaundal Soni, Villarreal Johanna, Gupta Yogesh K, Qiao Mei, Hubert Christopher G, Hart Matthew J, Penalva Luiz O F
Abstract excerpt
RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most aggressive brain tumor type. Msi1 expression levels are often high in GBMs and other tumor types and correlate with poor clinical outcome. Moreover, Msi1 has been implicated in chemo- and radio-resistance....
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