Article
Small-molecule Ro-08-2750 interacts with many RNA-binding proteins and elicits MUSASHI2-independent phenotypes.
RNA (New York, N.Y.) - 1 Oct 2023
Walters Kathryn, Sajek Marcin Piotr, Murphy Elisabeth, Issaian Aaron, Baldwin Amber, Harrison Evan, Daniels Miles, Reisz Julie A, Hansen Kirk, D'Alessandro Angelo, Mukherjee Neelanjan
Abstract excerpt
RNA-binding proteins (RBPs) are key regulators of gene expression. Small molecules targeting these RBP-RNA interactions are a rapidly emerging class of therapeutics for treating a variety of diseases. Ro-08-2750 (Ro) is a small molecule identified as a competitive inhibitor of Musashi (MSI)-RNA interactions. Here, we show that multiple Ro-dependent cellular phenotypes, specifically adrenocortical steroid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.