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Article

An immunoproteomic approach to characterize the CAR interactome and signalosome

12 Feb 2019

Abstract excerpt

Adoptive transfer of T cells that express a chimeric antigen receptor (CAR) is an approved immunotherapy that may be curative for some hematological cancers. To better understand the therapeutic mechanism of action, we systematically analyzed CAR signaling in human primary T cells by mass spectrometry. When we compared the interactomes and the signaling pathways activated by distinct CAR-T cells that shared the...

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PMID: 30755478
DOI: 10.1126/scisignal.aap9777

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