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Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions

19 Jun 2020

Abstract excerpt

Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapse has occurred in a substantial number of patients and limited the development of CAR-T therapy. Most underlying reasons can be attributed to poor persistence and rapid exhaustion of CAR-T cell in vivo. Despite multiple strategies developed, how to improve CAR-T...

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PMID: 32636832
DOI: 10.3389/fimmu.2020.01046

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