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Cognate Nanovaccine Promotes Tertiary Lymphoid Structures Function and Strengthens Immune Cell Cross-Talk by Targeting Exhausted T Cells in Nonimmunogenic Cancers

6 Jun 2025

Abstract excerpt

Tertiary lymphoid structures (TLSs) serve as hubs for immune cell activation and coordination to generate qualitative local immune responses within tumors. However, the effect of TLSs in pancreatic adenocarcinoma is limited by a poorly immunogenic tumor microenvironment and severe T-cell exhaustion. In this study, we found that tumor-infiltrating T cells, particularly TLS-associated T cells, predominantly exhibit...

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PMID: 40478679
DOI: 10.1021/acsnano.5c01280

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