Article

Increased hippocampal epigenetic age in the Ts65Dn Mouse Model of Down Syndrome

2023-09-25

Abstract excerpt

Down syndrome (DS) is a segmental progeroid genetic disorder associated to multi-systemic precocious ageing phenotypes, which are particularly evident at the immune and nervous systems. Accordingly, people with DS show an increased biological age as measured by epigenetic clocks. Ts65Dn trisomic mouse, which harbors extra-numerary copies of Hsa21-syntenic regions, was shown to recapitulate several progeroid featur...

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Literature Corpus work: b32ce18e-158f-5e1e-89f9-9effb50563fc
DOI: 10.1101/2023.09.25.559272

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