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Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model

4 May 2024

Abstract excerpt

Down syndrome (DS) is the most common condition with intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on HSA21 is associated with early neurodevelopmental changes and subsequently at adult age with the development of Alzheimer-like cognitive decline. However, the molecular mechanisms promoting brain pathology along aging are still missing. The...

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PMID: 38705491
DOI: 10.1016/j.nbd.2024.106523

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