Article

Novel mouse models for perianal fistulizing Crohn’s disease reveal therapeutic value of interferon-γ antagonists

2026-06-08

Abstract excerpt

<h4>Background and Aims</h4> Perianal fistulizing Crohn’s disease (PFCD) is a challenging complication with poorly understood pathogenesis and limited treatment options, largely due to the lack of clinically relevant animal models. Interferon-gamma (IFN-γ) signaling is hyperactivated in human PFCD. We aimed to establish mouse models recapitulating human PFCD and to evaluate IFN-γ as a new therapeutic target. <h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2ed5c5f-b494-564e-afae-9fd5b147ac3c
DOI: 10.64898/2026.06.04.730162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel mouse models for perianal fistulizing Crohn’s disease reveal therapeutic value of interferon-γ antagonistsDOI 10.64898/2026.06.04.730162Read

Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn’s DiseaseSemantic proximity Read

UNRAVELLING A HIDDEN SUBTYPE: MULTIOMICS REVEAL PSORIASIS-LIKE SIGNATURE WITH SURGICAL RELEVANCE IN A SUBSET OF PERIANAL FISTULIZING CROHN’S DISEASESemantic proximity Read

Invariant natural killer T-cell and CD4 <sup>+</sup> T-cell derived IL22 is a regulator of epithelial-to-mesenchymal transition and extracellular matrix remodelling in perianal fistulasSemantic proximity Read

TL1A-activated T cells remodel the rectal mucosa in Crohn’s disease patients with perianal fistulizing diseaseSemantic proximity Read

Clinical updates on perianal fistulas in Crohn's disease.Semantic proximity Read

Nuclear Calprotectin mediates Epithelial Wound Healing Defects in Crohn’s Disease related FistulaSemantic proximity Read

Results of the Fifth Scientific Workshop of the ECCO (II): Pathophysiology of Perianal Fistulizing Disease.Semantic proximity Read

Novel Transcriptomic Signatures in Fibrostenotic Crohn’s Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic TargetsSemantic proximity Read

Exploring Perianal Fistulas: Insights into Biochemical, Genetic and Epigenetic Influences – a Comprehensive ReviewSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Human adipose-derived mesenchymal stromal cells improved wound healing in enterocutaneous fistulizing disease mouse modelSemantic proximity Read

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s diseaseSemantic proximity Read