Article

Invariant natural killer T-cell and CD4 <sup>+</sup> T-cell derived IL22 is a regulator of epithelial-to-mesenchymal transition and extracellular matrix remodelling in perianal fistulas

2023-09-14

Abstract excerpt

<h4>Background and aims</h4> Perianal fistulization is a challenging phenotype of Crohn’s disease (CD). Unravelling the cytokine networks and cellular mediators driving tissue injury in perianal CD (pCD) will help inform much needed novel treatment strategies. <h4>Methods</h4> The phenotype of different T-cell subsets, including unconventional lineages, such as γδ T-cells, MAIT and iNKT-cells in fistula tract ti...

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Literature Corpus work: f8451964-438f-562b-9dd2-ac2056f309bf
DOI: 10.1101/2023.09.11.557122

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