Article

Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease

2025-04-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The deposition of toxic aggregated amyloid-β (Aβ) is a key pathogenic event in Alzheimer's disease (AD), resulted from the continuous cleavage of amyloid precursor protein (APP) by BACE1 (β-site APP cleaving enzyme 1) and γ-secretase. Small interfering RNA (siRNA) has shown great potential for disease treatment by specifically silencing target gene. However, the...

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Literature Corpus work: f7087781-727d-52b8-be07-c7310140b9cd
DOI: 10.21203/rs.3.rs-5825677/v1

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