Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes.

Theranostics - 1 Jan 2024

Peng Dong, Liu Tingting, Lu Huahui, Zhang Lei, Chen Hongxia, Huang Yadong, Hu Bo, Zhang Qihao

Abstract excerpt

Rationale: The level of miR-206-3p in the plasma and temporal cortex is increased in Alzheimer's disease (AD) patients. miR-206-3p antagomir injected into hippocampus ameliorates cognitive deficits by enhancing the level of BDNF. However, the trauma caused by brain injection and susceptibility to degradation limit its application. Methods: To overcome these challenges, we constructed engineered extracellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Intranasal
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Brain-Derived Neurotrophic Factor

Share to Extracellular Vesicles

Share to Hippocampus

Share to Mesenchymal Stem Cells

Share to MicroRNAs

Share to Neurogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 39659569
DOI: 10.7150/thno.103596
PMCID: PMC11626949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes.PMID 39659569Read ↗

Intranasal Delivery of 3D-Bioprinted Mesenchymal Stem Cell-Derived Extracellular Vesicles Targeting Aβ Deposition and Neuroinflammation for Alzheimer’s Disease TherapySemantic proximity Read ↗

Extracellular vesicles derived from astrocyte-treated with haFGF14-154 attenuate Alzheimer phenotype in AD mice.Semantic proximity Read ↗

Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer's DiseaseSemantic proximity Read ↗

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.Semantic proximity Read ↗

Porcine plasma-derived extracellular vesicles orchestrate multi- target neuroimmune reconfiguration to alleviate Alzheimer's diseaseSemantic proximity Read ↗

Application of Multiomics Approach to Investigate the Therapeutic Potentials of Stem Cell-derived Extracellular Vesicle Subpopulations for Alzheimer’s DiseaseSemantic proximity Read ↗

Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer’s ModelSemantic proximity Read ↗

Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumptionSemantic proximity Read ↗

Engineered extracellular vesicles targeting BACE1 reduces amyloid-beta plaque formation in a genetic mouse model of Alzheimer’s DiseaseSemantic proximity Read ↗

Engineered MSC-EVs Loaded with BDNF-Enhancing Neuropeptides via a Non-Disruptive Method Enhance Post-Stroke Neuroregeneration via Intranasal DeliverySemantic proximity Read ↗

Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Aβ-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau PhosphorylationSemantic proximity Read ↗

Relationships of Alzheimer’s disease and apolipoprotein E genotypes with small RNA and protein cargo of brain tissue extracellular vesiclesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.