Article

Delivery of BACE1 siRNA mediated by TARBP-BTP fusion protein reduces β-amyloid deposits in a transgenic mouse model of Alzheimer’s Disease

2016-12-28

Abstract excerpt

Systemic delivery of nucleic acids to the central nervous system (CNS) is a major challenge for the development of RNA interference-based therapeutics due to absence of stability, target specificity, non-permeability to the blood-brain barrier (BBB), and mainly due to lack of suitable carriers. Using a designed bi-functional fusion protein TARBP-BTP, very recently we demonstrated knockdown of target genes in the b...

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Literature Corpus work: 3ec0ed04-5448-5cf4-a826-f8b042a6310f
DOI: 10.1101/097121

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