Article

Kcnq2/Kv7.2 controls the threshold and bihemispheric symmetry of cortical spreading depolarization

2020-11-27

Abstract excerpt

Spreading depolarization (SD) is a slowly propagating wave of massive cellular depolarization associated with acute brain injury and migraine aura. Genetic studies link molecular defects in enhanced cytoplasmic Ca 2+ flux, glial Na + -K + ATPase, and interneuronal Na + current with SD susceptibility, emphasizing the important roles of synaptic activity and extracellular ionic homeostasis in determining SD thre...

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Literature Corpus work: b2be2877-3d70-5b07-b894-0b176b0a04ee
DOI: 10.1101/2020.11.27.401570

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