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Article

Time-limited alterations in cortical activity of a Knock-in mice model of <i>KCNQ2-</i> related Developmental and Epileptic Encephalopathy

2020-05-14

Abstract excerpt

De novo missense variants in the KCNQ2 gene encoding the Kv7.2 subunit of the voltage-gated potassium Kv7/M channel are the main cause of Developmental and Epileptic Encephalopathy (DEE). KCNQ2 related-DEE is characterized by pharmaco-resistant neonatal seizures associated with a developmental delay. While seizures usually resolve some weeks or months after birth, cognitive/behavioral deficits persist. To better...

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Literature Corpus work
0976dfec-5605-5f66-a53a-27c7c251e02e
DOI
10.1101/2020.05.12.090464
Open publication

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