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Article

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.

Science translational medicine - 8 Apr 2015

Aiba Isamu, Noebels Jeffrey L

Abstract excerpt

Cardiorespiratory collapse after a seizure is the leading cause of sudden unexpected death in epilepsy (SUDEP) in young persons, but why only certain individuals are at risk is unknown. To identify a mechanism for this lethal cardiorespiratory failure, we examined whether genes linked to increased SUDEP risk lower the threshold for spreading depolarization (SD), a self-propagating depolarizing wave that silences...

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Identifiers

PMID: 25855492
DOI: 10.1126/scitranslmed.aaa4050
PMCID: PMC4852131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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