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Article

Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction.

Epilepsia open - 1 Feb 2026

Bidwell Jessa S, Vanoye Carlos G, Desai Reshma R, Berg Anne T, George Alfred L

Abstract excerpt

OBJECTIVE: Variants in KCNQ2 encoding the voltage-gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity. This study examined the relationship of KCNQ2 variant dysfunction with the neurodevelopmental phenotype of individuals with KCNQ2-DEE. METHODS: A parent-reported survey gathered clinical and genetic data for individuals with KCNQ2-DEE. Several...

Topics

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Anticonvulsants
Carbamates
Child, Preschool
Epilepsy
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

KCNQ2 Potassium Channel

Neurodevelopmental Disorders

Phenylenediamines

Source

Open in PubMed Open full text

Identifiers

PMID: 41250984
DOI: 10.1002/epi4.70192
PMCID: PMC12903803

Genes

KCNQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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