Article

ASPPs multimerize protein phosphatase 1

2025-05-19

Abstract excerpt

Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown. The Ankyrin repeat, SH3-domain, and Proline-rich region containing Proteins (ASPPs) bind and localize PP1 to cell-cell junctions. Here, we show ASPPs bind superstoichiometric amounts of PP1. Missense mutations in the ankyrin repeats of ASPP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2bb9d04-de9d-5865-b08d-d43cff950251
DOI: 10.1101/2025.05.16.654433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ASPPs multimerize protein phosphatase 1DOI 10.1101/2025.05.16.654433Read

The <i>C. elegans</i> ASPP homolog APE-1 is a junctional protein phosphatase 1 modulatorSemantic proximity Read

Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.Semantic proximity Read

Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics.Semantic proximity Read

The inositol 5-phosphatase INPP5K participates in the fine control of ER organizationSemantic proximity Read

Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans.Semantic proximity Read

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in <i>C. elegans</i>Semantic proximity Read

PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans.Semantic proximity Read

Protein phosphatase 1 down regulates ZYG-1 levels to limit centriole duplicationSemantic proximity Read

PPM-1, a PP2Cα/β phosphatase, Regulates Axon Termination and Synapse Formation in <i>Caenorhabditis elegans</i>Semantic proximity Read

Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins.Semantic proximity Read

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.Semantic proximity Read

Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp‐1Semantic proximity Read