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Article

Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.

Molecular biology of the cell - 15 Aug 2018

Qadota Hiroshi, Matsunaga Yohei, Bagchi Pritha, Lange Karen I, Carrier Karma J, Pols William Vander, Swartzbaugh Emily, Wilson Kristy J, Srayko Martin, Pallas David C, Benian Guy M

Abstract excerpt

Protein phosphatase 2A (PP2A) is a heterotrimer composed of single catalytic and scaffolding subunits and one of several possible regulatory subunits. We identified PPTR-2, a regulatory subunit of PP2A, as a binding partner for the giant muscle protein UNC-89 (obscurin) in Caenorhabditis elegans. PPTR-2 is required for sarcomere organization when its paralogue, PPTR-1, is deficient. PPTR-2 localizes to the...

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PMID: 29949401
DOI: 10.1091/mbc.E18-03-0192
PMCID: PMC6232960

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Source receipt: pubmed, retrieved 7 Sept 2026.

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