Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPM-1, a PP2Cα/β phosphatase, Regulates Axon Termination and Synapse Formation in <i>Caenorhabditis elegans</i>

4 Oct 2011

Abstract excerpt

The PHR (Pam/Highwire/RPM-1) proteins are evolutionarily conserved ubiquitin ligases that regulate axon guidance and synapse formation in Caenorhabditis elegans, Drosophila, zebrafish, and mice. In C. elegans, RPM-1 (Regulator of Presynaptic Morphology-1) functions in synapse formation, axon guidance, axon termination, and postsynaptic GLR-1 trafficking. Acting as an E3 ubiquitin ligase, RPM-1 negatively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21968191
DOI: 10.1534/genetics.111.134791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPM-1, a PP2Cα/β phosphatase, Regulates Axon Termination and Synapse Formation in <i>Caenorhabditis elegans</i>PMID 21968191Read ↗

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.Semantic proximity Read ↗

Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.Semantic proximity Read ↗

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.Semantic proximity Read ↗

rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.Semantic proximity Read ↗

Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.Semantic proximity Read ↗

RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.Semantic proximity Read ↗

Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.Semantic proximity Read ↗

Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.Semantic proximity Read ↗

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hubSemantic proximity Read ↗

RPM-1, a Caenorhabditis elegans protein that functions in presynaptic differentiation, negatively regulates axon outgrowth by controlling SAX-3/robo and UNC-5/UNC5 activity.Semantic proximity Read ↗

A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.