Article

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

2019-03-14

Abstract excerpt

<h4>SUMMARY</h4> Epithelial tissues are highly sensitive to anisotropies in mechanical force, with cells altering fundamental behaviours such as cell adhesion, migration and cell division [1-5]. It is well known that in the later stages of carcinoma (epithelial cancer), the presence of tumours alters the mechanical properties of a host tissue and that these changes contribute to disease progression [6-9]. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2a1d0cf-09df-5155-ba0e-4ff25d1493c7
DOI: 10.1101/578146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissueDOI 10.1101/578146Read

Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cellsSemantic proximity Read

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia.Semantic proximity Read

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epitheliaSemantic proximity Read

Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesisSemantic proximity Read

Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered TractionsSemantic proximity Read

<i>In vivo</i> nuclear envelope adaptation during cell migration across confining embryonic tissue environmentsSemantic proximity Read

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Semantic proximity Read

Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongationSemantic proximity Read

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and CancerSemantic proximity Read

Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin networkSemantic proximity Read

Are cancer cells really softer than normal cells?Semantic proximity Read

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanicsSemantic proximity Read