Article

Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis

2022-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Early lung cancer lesions develop within a unique microenvironment that undergoes constant cyclic stretch from respiration. While tumor stiffening is an established driver of tumor progression, the contribution of stress and strain to lung cancer is unknown. We developed tissue scale finite element models of lung tissue to test how early lesions alter respiration-induced strain. We found that an...

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Literature Corpus work: 8f4f5836-2235-5b75-b24e-7fcd1ea28a93
DOI: 10.1101/2022.05.03.490386

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