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Article

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer

14 Jun 2016

Abstract excerpt

Mechanical force modulates development, influences tissue homeostasis, and contributes to disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging mechanoreceptors and by altering organization of the cytoskeleton and actomyosin contractility to stimulate mechanotransduction mechanisms that alter transcription. Nevertheless, how force specifically leverages mechanotransduction pathways to...

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PMID: 27298087
DOI: 10.1146/annurev-cellbio-111315-125150

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