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Article

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics

13 Oct 2021

Abstract excerpt

in confined epithelial monolayers on soft substrates drives a morphological transformation of a 2D monolayer into a compact 3D cell aggregate. This transformation was initiated by the loss of monolayer integrity and formation of two distinct cell layers with differential cell-cell junctions, cell-substrate adhesion, and tensional states. Computational modeling revealed how adhesion and active peripheral tension...

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PMID: 34644109
DOI: 10.1126/sciadv.abg6467

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