Article

Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementia

2024-10-02

Abstract excerpt

Tau degradation is disrupted in neurodegenerative tauopathies, such as frontotemporal dementia (FTD), which may contribute to Tau aggregation. The prevailing hypothesis has been that Tau degradation is stymied due to an imbalance in proteostasis that occurs with age. Here, we used Airyscan super resolution imaging to illustrate that a pathogenic FTD mutation in the MAPT gene, which encodes Tau, is sufficient to a...

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Literature Corpus work: 26bd6fe8-054b-5db4-806d-9f30025aba30
DOI: 10.1101/2024.09.30.615921

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