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A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans

10 Sept 2020

Abstract excerpt

The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable of neutralizing the APOBEC3 enzymes of the new host. Although much is known about current interactions of HIV-1 Vif...

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PMID: 32913367
DOI: 10.1371/journal.ppat.1008812

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