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Article

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present.

Viruses - 17 Jan 2021

Uriu Keiya, Kosugi Yusuke, Ito Jumpei, Sato Kei

Abstract excerpt

The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancient viruses. At present, lentiviruses, including HIV, the causative agent of AIDS, are known to...

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Identifiers

PMID: 33477360
DOI: 10.3390/v13010124
PMCID: PMC7830460

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